Symbol
Name
ID

Prx
periaxin
MGI:108176

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Tongue fasciculations

Increased CSF protein concentration

Difficulty walking

Decreased number of peripheral myelinated nerve fibers

Decreased number of large peripheral myelinated nerve fibers

Onion bulb formation

Basal lamina onion bulb formation

Peripheral demyelination

Segmental peripheral demyelination/remyelination

Myelin tomacula

Hypertrophic nerve changes

Gait ataxia

Vocal cord paresis

Decreased motor nerve conduction velocity

Decreased sensory nerve conduction velocity

Areflexia

Hyporeflexia

Broad-based gait

Loss of ambulation

Steppage gait

Motor delay

Distal sensory impairment

Impaired distal vibration sensation

Sensory ataxia

Disease(s) Associated with PRX

Charcot-Marie-Tooth disease type 3

Charcot-Marie-Tooth disease type 4F

Mouse Phenotypes		nervous system phenotype	absent Cajal-Retzius cell	abnormal Schwann cell morphology	increased Schwann cell number	abnormal internode morphology	abnormal myelination	abnormal nervous system electrophysiology	abnormal action potential	abnormal nerve conduction	decreased nerve conduction velocity
Availability	Mouse Genotype	nervous system phenotype	absent Cajal-Retzius cell	abnormal Schwann cell morphology	increased Schwann cell number	abnormal internode morphology	abnormal myelination	abnormal nervous system electrophysiology	abnormal action potential	abnormal nerve conduction	decreased nerve conduction velocity
	Prx^tm1Brp/Prx^tm1Brp
	Prx^tm1Brp/Prx^tm1Brp Tg(Mpz/GJB1-Prx*)#Brp/0	*
	Prx^tm2.1Brp/Prx^tm2.1Brp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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